/* Apple-inspired design system for medical content */

/* Reset and base styles */
* {
  margin: 0;
  padding: 0;
  box-sizing: border-box;
}

html {
  scroll-behavior: smooth;
}

body {
  font-family: -apple-system, BlinkMacSystemFont, 'Segoe UI', 'Roboto', 'Helvetica Neue', Arial, sans-serif;
  line-height: 1.6;
  color: #334155;
  overflow-x: hidden;
}

/* Custom scrollbar */
::-webkit-scrollbar {
  width: 8px;
}

::-webkit-scrollbar-track {
  background: #f1f5f9;
}

::-webkit-scrollbar-thumb {
  background: #cbd5e1;
  border-radius: 4px;
}

::-webkit-scrollbar-thumb:hover {
  background: #94a3b8;
}

/* Typography enhancements */
h1, h2, h3, h4, h5, h6 {
  font-weight: 600;
  line-height: 1.2;
  color: #0f172a;
}

.text-gradient {
  background: linear-gradient(135deg, #3b82f6, #1d4ed8);
  -webkit-background-clip: text;
  -webkit-text-fill-color: transparent;
  background-clip: text;
}

/* Smooth animations */
.animate-fade-in {
  animation: fadeIn 0.8s ease-out;
}

.animate-slide-up {
  animation: slideUp 0.8s ease-out;
}

.animate-float {
  animation: float 6s ease-in-out infinite;
}

@keyframes fadeIn {
  from {
    opacity: 0;
    transform: translateY(20px);
  }
  to {
    opacity: 1;
    transform: translateY(0);
  }
}

@keyframes slideUp {
  from {
    opacity: 0;
    transform: translateY(40px);
  }
  to {
    opacity: 1;
    transform: translateY(0);
  }
}

@keyframes float {
  0%, 100% {
    transform: translateY(0px);
  }
  50% {
    transform: translateY(-10px);
  }
}

/* Glass morphism effects */
.glass {
  background: rgba(255, 255, 255, 0.9);
  backdrop-filter: blur(20px);
  -webkit-backdrop-filter: blur(20px);
  border: 1px solid rgba(255, 255, 255, 0.2);
}

/* Hover effects */
.hover-lift {
  transition: all 0.3s cubic-bezier(0.4, 0, 0.2, 1);
}

.hover-lift:hover {
  transform: translateY(-4px);
  box-shadow: 0 20px 25px -5px rgba(0, 0, 0, 0.1), 0 10px 10px -5px rgba(0, 0, 0, 0.04);
}

/* Custom button styles */
.btn-primary {
  background: linear-gradient(135deg, #3b82f6, #1d4ed8);
  color: white;
  padding: 12px 32px;
  border-radius: 16px;
  font-weight: 600;
  text-decoration: none;
  display: inline-flex;
  align-items: center;
  gap: 8px;
  transition: all 0.3s ease;
  border: none;
  cursor: pointer;
}

.btn-primary:hover {
  background: linear-gradient(135deg, #2563eb, #1e40af);
  transform: translateY(-2px);
  box-shadow: 0 10px 20px rgba(59, 130, 246, 0.3);
}

.btn-secondary {
  background: rgba(255, 255, 255, 0.9);
  color: #334155;
  padding: 12px 32px;
  border-radius: 16px;
  font-weight: 600;
  text-decoration: none;
  display: inline-flex;
  align-items: center;
  gap: 8px;
  transition: all 0.3s ease;
  border: 1px solid #e2e8f0;
  cursor: pointer;
}

.btn-secondary:hover {
  background: #f8fafc;
  transform: translateY(-2px);
  box-shadow: 0 10px 20px rgba(0, 0, 0, 0.1);
}

/* Card styles */
.card {
  background: white;
  border-radius: 24px;
  padding: 32px;
  box-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1);
  transition: all 0.3s ease;
  border: 1px solid #f1f5f9;
}

.card:hover {
  box-shadow: 0 20px 25px -5px rgba(0, 0, 0, 0.1);
  transform: translateY(-4px);
}

.card-gradient {
  background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
  color: white;
}

/* Progress bars */
.progress-bar {
  width: 100%;
  height: 8px;
  background: #e2e8f0;
  border-radius: 4px;
  overflow: hidden;
}

.progress-fill {
  height: 100%;
  border-radius: 4px;
  transition: width 0.8s ease;
}

/* Navigation styles */
nav {
  backdrop-filter: blur(20px);
  -webkit-backdrop-filter: blur(20px);
}

nav a {
  transition: color 0.3s ease;
}

nav a:hover {
  color: #3b82f6;
}

/* Section spacing */
section {
  padding: 80px 0;
}

@media (max-width: 768px) {
  section {
    padding: 60px 0;
  }
}

/* Responsive design */
.container {
  max-width: 1280px;
  margin: 0 auto;
  padding: 0 24px;
}

@media (max-width: 640px) {
  .container {
    padding: 0 16px;
  }
}

/* Medical data visualization */
.stats-grid {
  display: grid;
  grid-template-columns: repeat(auto-fit, minmax(200px, 1fr));
  gap: 24px;
  margin-top: 40px;
}

.stat-card {
  text-align: center;
  padding: 24px;
  background: white;
  border-radius: 16px;
  box-shadow: 0 4px 6px -1px rgba(0, 0, 0, 0.1);
  transition: all 0.3s ease;
}

.stat-card:hover {
  transform: translateY(-2px);
  box-shadow: 0 10px 20px rgba(0, 0, 0, 0.1);
}

.stat-number {
  font-size: 2.5rem;
  font-weight: 700;
  color: #3b82f6;
  display: block;
}

/* Research paper cards */
.paper-card {
  background: linear-gradient(135deg, #f8fafc 0%, #e2e8f0 100%);
  border-radius: 20px;
  padding: 24px;
  margin-bottom: 20px;
  border-left: 4px solid #3b82f6;
  transition: all 0.3s ease;
}

.paper-card:hover {
  transform: translateX(8px);
  box-shadow: 0 10px 20px rgba(0, 0, 0, 0.1);
}

.paper-title {
  font-weight: 600;
  color: #1e293b;
  margin-bottom: 8px;
  font-size: 1.1rem;
}

.paper-authors {
  color: #64748b;
  font-size: 0.9rem;
  margin-bottom: 4px;
}

.paper-journal {
  color: #3b82f6;
  font-size: 0.85rem;
  font-weight: 500;
}

/* Loading animations */
.loading {
  display: inline-block;
  width: 20px;
  height: 20px;
  border: 3px solid #f3f4f6;
  border-radius: 50%;
  border-top-color: #3b82f6;
  animation: spin 1s ease-in-out infinite;
}

@keyframes spin {
  to {
    transform: rotate(360deg);
  }
}

/* Print styles */
@media print {
  body {
    color: black;
  }
  
  .no-print {
    display: none;
  }
  
  .print-break {
    page-break-before: always;
  }
}

/* High contrast mode support */
@media (prefers-contrast: high) {
  .card {
    border: 2px solid #000;
  }
  
  .btn-primary {
    border: 2px solid #000;
  }
}

/* Reduced motion support */
@media (prefers-reduced-motion: reduce) {
  * {
    animation-duration: 0.01ms !important;
    animation-iteration-count: 1 !important;
    transition-duration: 0.01ms !important;
  }
  
  html {
    scroll-behavior: auto;
  }
}

/* Focus styles for accessibility */
button:focus,
a:focus {
  outline: 2px solid #3b82f6;
  outline-offset: 2px;
}

/* Custom utilities */
.text-shadow {
  text-shadow: 0 2px 4px rgba(0, 0, 0, 0.1);
}

.backdrop-blur {
  backdrop-filter: blur(12px);
  -webkit-backdrop-filter: blur(12px);
}

.border-gradient {
  background: linear-gradient(white, white) padding-box,
              linear-gradient(135deg, #3b82f6, #1d4ed8) border-box;
  border: 1px solid transparent;
}